Research Highlights

  • soft brain-machine interface

    Brain-machine interface

    Map brain activity at single-cell-single-spike resolution with cell-type specificity via soft nanoelectronics-brain interface

  • cyborg cardiac organoid

    Cyborg organoids

    Tissue-wide integration of nanoelectronics through organogenesis for AI-enabled control

  • GTCA

    Genetically-targeted bioelectronics

    Assembly of genetically-targeted, tissue-wide bioelectronics through synthetic biology

  • cardiac mapping

    Cardiac mapping at cellular resolution

    Long-term stable, high-density mapping of cardiac arrhythmia at cellular resolution

  • Tissue-like electronics

    Tissue-like electronics

    Tissue-level soft semiconductor-based bioelectronics

ABOUT THE LIU LAB

Jia Liu's group at Harvard brings together researchers from Bioengineering, Electrical Engineering, Chemistry, Bioinformatics, Computer Science, and Materials Science and Mechanical Engineering to develop advanced bioelectronics that integrates nanoelectronics, soft electronics, cyborg engineering, genetic and genomic engineering, imaging and computational tools for interfacing with biological systems and digitizing their dynamics. Specifically, we are working on tools and platforms capable of mapping and controlling multimodal single-cell activities across time and space from a statistically significant number of cells in living organisms and behaving animals with cell-type specificity. Leveraging our experimental and computational expertise, we aim to study the relationship between population dynamics of single-cell multimodal physiology and gene expression, and whole-organ/organism level functions and dysfunctions to address questions in brain-machine interface, neuroscience, cardiac diseases and developmental disorders.

Postdoctoral, graduate student, fellow/research assistant, and visiting scholar/visiting undergraduate research intern positions are all currently available.  Please go to our Openings page for more details.

We recruit Ph.D. students who are interested in nanoelectronics, bioelectronics, soft electronics, bio-imaging, genomics, genetics, and electrical engineering and computer science.

We also have special positions for Masters and Ph.D. students who are working in the fields of artificial intelligence, machine learning, statistics, bioinformatics, computational neuroscience, and general computational biology.

RECENT NEWS AND PUBLICATIONS

NEWS

RECENT PUBLICATIONS

9/17/2021We are incredibly grateful to receive the NIH/NIDDK Catalyst Award (DP1 Pioneer Award Program) to support our work! 

9/01/2021We are excited to launch a startup from our lab, Axoft Inc., led by PhD graduate, Paul Le Floch, to revolutionize the brain-machine interface by making implantable electronics as soft as the brain. The Engine is leading the investment. https://engine.xyz/founders/axoft/

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8/20/2021We welcome new graduate student Ariel Lee to the lab. Ariel has received the GRFP from NSF. Congratulations!

6/16/2021First graduate student from our group, Paul Le Floch, successfully defended his Ph.D. Congratulations!!!

Paul Thesis Defense

6/1/2021The Bio-integration lab of Harvard Liu Lab has been moved to the Harvard new Engineering Campus, Science and Engineering Complex (SEC, https://youtu.be/a2kIFoa5Iuc), featuring state-of-the-art facilities for Bioengineering, Computer Science, Data Science, and Robotics. Our Electronics lab will be kept in Harvard Cambridge Campus with the Harvard Center for Nanoscale Systems. 

5/1/2021We welcome new graduate students Yichun He and Jaeyong Lee to the lab. Yichun has received the James Mills Peirce Fellowship from the Graduate School of Arts and Sciences, Harvard University. Jaeyong has received a fellowship from Kwanjeong Education Foundation. Congratulations!

3/25/2021Jia Liu has been awarded a LInc Faculty Fellowship for the 2021-2022 academic year. Many thanks to The Learning Incubator at Harvard John A. Paulson School of Engineering and Applied Sciences for this fellowship.

2/2/2021:  The group receives a two-year seed award in collaboration with Harvard University's Materials Research Science and Engineering Center to support the bioelectronics research. We are grateful to the NSF for their support.

1/11/2021Emma Bou Hanna and Sebastian Partarrieu, both from Mines ParisTech, join the lab as Visiting Undergraduate Research Interns, welcome! 

10/16/2020:  Jia Liu has been awarded the William F. Milton Award.  We are grateful to Harvard's Office of the Vice Provost for Research for this award.

9/30/2020:  Jia Liu has been invited to join the Harvard Brain Science Initiative. We appreciate the support from the Initiative. 

9/3/2020:  Bridget O'Kelly and Kazi Tasnim from Harvard College join the lab as undergraduate researchers, welcome! 

9/2/2020:  The group receives an NSF CPS award to support the collaborative work on AI, nanoelectronics, and stem cell biology. We are grateful to the NSF for their support.

8/25/2020:  The group receives an NIH R01 grant to support the cyborg organoids research. We are grateful to NIH for their support.

7/1/2020:  Daniel Solomon has been awarded Harvard College Research Program Fellowship. Congratulations!

5/1/2020:  Jia Liu has been awarded a Harvard Stem Cell Institute 2020 Seed Grant Award for his cyborg organoids project. We are grateful to the Institute for their support.

 

He Y, Tang T, Huang J, Ren J, Zhou H, Chen K, Liu A, Shi H, Lin Z, Li Q, Aditham A, Ounadjela J, Grody EI, Shu J, Liu J*, Wang X*. “ClusterMap for multi-scale clustering analysis of spatial gene expression. Nature Communications 12, 5909 (2021) https://doi.org/10.1038/s41467-021-26044-x

Tasnim K, Liu J*. (Invited perspective) Emerging bioelectronics for brain organoid electrophysiology. Journal of Molecular Biology (2021) https://www.sciencedirect.com/science/article/pii/S0022283621003958

Sessler CD, Huang Z, Wang X, Liu J*. (Invited review) Functional nanomaterial-enabled synthetic biology. Nano Futures 5, 022001 (2021) https://iopscience.iop.org/article/10.1088/2399-1984/abfd97

Liu R, S. Zhao S, Liu J*. (Invited review) From lithographically patternable to genetically patternable electronic materials for miniaturized, scalable, and soft implantable bioelectronics to interface with nervous and cardiac systems. ACS Appl. Electron. Mater. 3, 101-118 (2021) https://pubs.acs.org/doi/10.1021/acsaelm.0c00753

Liu J, Wang J, Zhang Z, Molina-Lopez F, Wang G-JN, Schroeder BC, Yan X, Zeng Y, Zhao O, Tran H, Lei T, Lu Y, Wang YX, Tok JB-H, Dauskardt R, Chung J, Yun Y, Bao Z. Fully stretchable active-matrix organic light-emitting electrochemical cell array. Nature Communications 11, 3362 (2020) https://www.nature.com/articles/s41467-020-17084-w.

Liu J, Zhang X, Liu Y, Rodrigo M, Loftus PD, Aparicio-Valenzuela J, Zheng J, Pong T, Cyr KJ, Babakhanian M, Hasi J, Li J, Jiang Y, Kenney CJ, Wang PJ, Lee AM, Bao Z. Intrinsically stretchable electrode array enabled in vivo electrophysiological mapping of atrial fibrillation at cellular resolution. Proc. Natl. Acad. Sci. USA 117, 14769-14778 (2020) https://www.pnas.org/content/early/2020/06/10/2000207117.

Zhang S, Wang Y, Yao X, Le Floch, P, Yang X, Liu J, Suo Z. Stretchable electrets: nanoparticle-elastomer composites. Nano Letters 20, 4580–4587 (2020). https://doi.org/10.1021/acs.nanolett.0c01434

Liu J, Kim Y, Richardson C, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert L-M, Jiang Y, Wang H, Fenno L, Tok B-HJ, Pasca S, Shen K, Bao Z, Deisseroth K. Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. Science 367, 1372-1376 (2020). https://science.sciencemag.org/content/367/6484/1372.full. For two perspectives on this publication from Science Magazine, please see article by K.J. Otto and C.E. Schmidt and article by S. Mao. For perspective and highlight on this publication from Nature Methods, please see article by Nina Vogt.

                                                    Science Magazine
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Le Floch, P., N. Molinari, K. Nan, S. Zhang, B. Kozinsky, Z. Suo and J. Liu. Fundamental limits to the electrochemical impedance stability of dielectric elastomers in bioelectronics. Nano Letters 20, 224-233 (2020) https://pubs.acs.org/doi/10.1021/acs.nanolett.9b03705.

                                                    Nano Letters

Li, Q., K. Nan, P. LeFloch, Z. Lin, H. Sheng, T.S. Blum and J. Liu. Cyborg organoids:  Implantation of nanoelectronics via organogenesis for tissue-wide electrophysiology.  Nano Letters 19, 5781-5789 (2019)  https://doi.org/10.1021/acs.nanolett.9b02512. Please click here for the Harvard Gazette news item about this, and click here for Harvard School of Engineering and Applied Sciences news item.  For more press on this article, please go to our Press page.

                                                    Nano Letters