Research Highlights

  • soft brain-machine interface

    Brain-machine interface

    Digitizing of brain activity with single-cell resolution, cell-type specificity through soft nanoelectronics-tissue integration

  • cyborg cardiac organoid

    Cyborg organoids

    Tissue-wide integration of nanoelectronics through organogenesis

  • GTCA

    Genetically-targeted bioelectronics

    Assembly of genetically-targeted, tissue-wide bioelectronics through synthetic biology

  • cardiac mapping

    In vivo cardiac mapping at cellular resolution

    Long-term stable, high-density mapping of atrial fibrillation at cellular resolution for local focal points identification

  • Tissue-like electronics

    Tissue-like electronics

    Combination of materials science, electrical engineering and mechanical engineering for electronics with tissue-like properties

ABOUT THE LIU LAB

Jia Liu's group at Harvard brings together researchers from Bioengineering, Electrical Engineering, Chemistry, Bioinformatics, Computer Science, and Materials Science and Mechanical Engineering to develop advanced nanoelectronic, cyborg engineering, genetic and genomic engineering, imaging and computational tools and platforms for digitizing the dynamics of biological systems. Specifically, we are working on tools and platforms capable of mapping and controlling multimodal single-cell activities across time and space from a statistically significant number of cells in living organisms and behaving animals with cell-type specificity. Leveraging our experimental and computational expertise, we aim to study the relationship between population dynamics of single-cell multimodal physiology and gene expression, and whole-organ/organism level functions and dysfunctions to address questions in brain-machine interface, neuroscience, cardiac diseases and developmental disorders.

Postdoctoral, graduate student, fellow/research assistant, and visiting scholar/visiting undergraduate research intern positions are all currently available.  Please go to our Openings page for more details.

We recruit Ph.D. students who are interested in soft nanoelectronics or bio-imaging. We also have special positions for Masters and Ph.D. students who are working in the fields of artificial intelligence, machine learning, statistics, bioinformatics, computational neuroscience, and general computational biology.

RECENT NEWS AND PUBLICATIONS

NEWS

RECENT PUBLICATIONS

1/11/2021Emma Bou Hanna and Sebastian Partarrieu, both from Mines ParisTech, join the lab as Visiting Undergraduate Research Interns, welcome! 

10/16/2020:  Jia Liu has been awarded the William F. Milton Award.  We are grateful to Harvard's Office of the Vice Provost for Research for this award.

9/30/2020:  Jia Liu has been invited to join the Harvard Brain Science Initiative. We appreciate the support from the Initiative. 

9/3/2020:  Bridget O'Kelly and Kazi Tasnim from Harvard College join the lab as undergraduate researchers, welcome! 

9/2/2020:  The group receives an NSF CPS award to support the collaborative work on AI, nanoelectronics, and stem cell biology. We are grateful to the NSF for their support.

8/25/2020:  The group receives an NIH R01 grant to support the cyborg organoids research. We are grateful to NIH for their support.

7/1/2020:  Daniel Solomon has been awarded Harvard College Research Program Fellowship. Congratulations!

5/1/2020:  Jia Liu has been awarded a Harvard Stem Cell Institute 2020 Seed Grant Award for his cyborg organoids project. We are grateful to the Institute for their support.

3/1/2020:  Ren Liu joins the lab as a postdoctoral fellow.  Welcome!  Ren received her PhD in Electrical Engineering at U.C. San Diego.

9/1/2019:  Two Aramont Fund for Emerging Science Fellowship awards have been granted to Jia Liu and to Hao Sheng of our group.  Jia has been awarded the Aramont Junior Faculty Fellowship. Hao has been awarded the Aramont Graduate Student Fellowship. We are very grateful to the Aramont Charitable Foundation for their generous support of our research. Please see the Harvard Gazette article for more information.

9/1/2019:  We welcome new graduate student Xin Tang to the lab.  Also joining the lab are Gaël Ancel and Charlene de Guitaut, Visiting Undergraduate Research Interns from Mines ParisTech, and Han Jiang, Research Fellow, MS, Boston University 2019.  Welcome all!

 

Liu R, Zhao S, Liu J. From lithographically patternable to genetically patternable electronic materials for miniaturized, scalable, and soft implantable bioelectronics to interface with nervous and cardiac systems. ACS Appl. Electron. Mater. (2020) https://dx.doi.org/10.1021/acsaelm.0c00753

Liu J, Wang J, Zhang Z, Molina-Lopez F, Wang G-JN, Schroeder BC, Yan X, Zeng Y, Zhao O, Tran H, Lei T, Lu Y, Wang YX, Tok JB-H, Dauskardt R, Chung J, Yun Y, Bao Z. Fully stretchable active-matrix organic light-emitting electrochemical cell array. Nature Communications. 11, 3362 (2020) https://www.nature.com/articles/s41467-020-17084-w.

Liu J, Zhang X, Liu Y, Rodrigo M, Loftus PD, Aparicio-Valenzuela J, Zheng J, Pong T, Cyr KJ, Babakhanian M, Hasi J, Li J, Jiang Y, Kenney CJ, Wang PJ, Lee AM, Bao Z. Intrinsically stretchable electrode array enabled in vivo electrophysiological mapping of atrial fibrillation at cellular resolution. Proc. Natl. Acad. Sci. USA 117, 14769-14778 (2020) https://www.pnas.org/content/early/2020/06/10/2000207117.

Zhang S, Wang Y, Yao X, Le Floch, P, Yang X, Liu J, Suo Z. Stretchable electrets: nanoparticle-elastomer composites. Nano Letters. 20, 4580–4587 (2020). https://doi.org/10.1021/acs.nanolett.0c01434

Liu J, Kim Y, Richardson C, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert L-M, Jiang Y, Wang H, Fenno L, Tok B-HJ, Pasca S, Shen K, Bao Z, Deisseroth K. Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. Science 367, 1372-1376 (2020). https://science.sciencemag.org/content/367/6484/1372.full. For two perspectives on this publication from Science Magazine, please see article by K.J. Otto and C.E. Schmidt and article by S. Mao. For perspective and highlight on this publication from Nature Methods, please see article by Nina Vogt.

                                                    Science Magazine
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Le Floch, P., N. Molinari, K. Nan, S. Zhang, B. Kozinsky, Z. Suo and J. Liu. Fundamental limits to the electrochemical impedance stability of dielectric elastomers in bioelectronics. Nano Letters 20, 224-233 (2020) https://pubs.acs.org/doi/10.1021/acs.nanolett.9b03705.

                                                    Nano Letters

Li, Q., K. Nan, P. LeFloch, Z. Lin, H. Sheng, T.S. Blum and J. Liu. Cyborg organoids:  Implantation of nanoelectronics via organogenesis for tissue-wide electrophysiology.  Nano Letters 19, 5781-5789 (2019)  https://doi.org/10.1021/acs.nanolett.9b02512. Please click here for the Harvard Gazette news item about this, and click here for Harvard School of Engineering and Applied Sciences news item.  For more press on this article, please go to our Press page.

                                                    Nano Letters